Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GGT1 | P19440 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14011294 | 0.74 | CA12 (0.36) | ATMCA12CA7CA9CA14 | |
| SCHEMBL7736011 | 0.72 | NOS2 (0.36) | NOS2GGT1ARG1ARG2 | |
| SCHEMBL3779377 | 0.72 | ATM (0.44) | ATMCA12CA7CA9CA14 | |
| SCHEMBL15904412 | 0.71 | CYP2C19 (0.43) | ATMCA12CA7CA9CA14 | |
| SCHEMBL6531413 | 0.70 | NOS2 (0.35) | NOS2ARG1ARG2 | |
| SCHEMBL63185 | 0.70 | NOS2 (0.49) | NOS2CYP2D6CYP2C19GGT1ALDH1A1 | |
| SCHEMBL11740166 | 0.70 | NOS2 (0.49) | NOS2CYP2D6CYP2C19GGT1ALDH1A1 | |
| SCHEMBL63003 | 0.70 | NOS2 (0.49) | NOS2CYP2D6CYP2C19GGT1ALDH1A1 | |
| SCHEMBL63144 | 0.70 | NOS2 (0.49) | NOS2CYP2D6CYP2C19GGT1ALDH1A1 | |
| SCHEMBL13584862 | 0.69 | SLC7A5 (0.45) | NOS2ATMCA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756498-A | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | claimed |
| US-5756498-A | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |