Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9075889 | 0.88 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8653337 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21750486 | 0.81 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8337315 | 0.80 | DRD1 (0.71) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8336449 | 0.79 | DRD2 (0.69) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21750481 | 0.79 | KMT2A (0.70) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21750484 | 0.79 | ALDH1A1 (0.70) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8336215 | 0.78 | DRD2 (0.67) | KDM4ESMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL8653340 | 0.78 | DRD2 (0.52) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7761407 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2LMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792870-A | 2-amino-3-aroyl-benzo β!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3- 4-(2-aminoethoxy)-benzoyl!benzo β!thiophenes | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| US-5512684-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |