Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8659710 | 0.92 | KIF11 (0.46) | HPGDALDH1A1LMNAKDM4EGFER | |
| SCHEMBL8661718 | 0.88 | HPGD (0.46) | HPGDALDH1A1LMNAKDM4EFFAR4 | |
| SCHEMBL8662990 | 0.88 | HPGD (0.46) | HPGDPGAM1HSPD1PTPN2PTPN1 | |
| SCHEMBL8663552 | 0.88 | HPGD (0.51) | HPGDALDH1A1LMNAKDM4EGFER | |
| SCHEMBL8659128 | 0.86 | HPGD (0.46) | HPGDPGAM1ALDH1A1LMNAKDM4E | |
| SCHEMBL8662978 | 0.86 | HPGD (0.46) | HPGDALDH1A1LMNAKDM4EFFAR4 | |
| SCHEMBL8663461 | 0.85 | PGAM1 (0.48) | PGAM1HSPD1PTPN2PTPN1PTPN5 | |
| SCHEMBL8659268 | 0.85 | TSHR (0.48) | HPGDALDH1A1LMNAKDM4EGFER | |
| SCHEMBL8659417 | 0.85 | HPGD (0.48) | HPGDALDH1A1LMNAKDM4EGFER | |
| SCHEMBL8657916 | 0.85 | HPGD (0.48) | HPGDALDH1A1LMNAKDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |