SCHEMBL8658677

SCHEMBL8658677

CCCCCSc1cccc([N+](=O)[O-])c1C#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.39
ALDH1A1 P00352 5/20 0.39
MAPT P10636 4/20 0.39
LMNA P02545 3/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.39
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
HPGD P15428 2/20 0.38
TP53 P04637 1/20 0.38
HSP90AA1 P07900 1/20 0.38
ATM Q13315 1/20 0.38
POLB P06746 1/20 0.36
GSTP1 P09211 4/20 0.36
GSTM2 P28161 4/20 0.36
TDP1 Q9NUW8 2/20 0.36
GAA P10253 1/20 0.35
ALPG P10696 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CYSLTR2 Q9NS75 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2416893 0.96 ALDH1A1 (0.40) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL1398094 0.85 ALDH1A1 (0.43) ALDH1A1MAPTLMNASMN1; SMN2ABCG2
SCHEMBL1347642 0.82 PTGS2 (0.49) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL9453031 0.80 PTGS2 (0.50) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL27613330 0.77 MEN1 (0.42) PTGS2ALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL8973221 0.77 PTGS2 (0.49) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL2415981 0.77 TDP1 (0.44) ALDH1A1MAPTLMNASMN1; SMN2ABCG2
SCHEMBL23751353 0.76 MEN1 (0.41) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL20787703 0.76 TSHR (0.47) PTGS2ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL7713273 0.76 MEN1 (0.44) PTGS2ALDH1A1MAPTSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723452-A Therapeutic benzonitriles GLAXO WELLCOME INC. (US) 1998-03-03 US disclosed
EP-0748311-A1 THERAPEUTIC BENZONITRILES THE WELLCOME FOUNDATION LIMITED (GB) 1996-12-18 EP disclosed
EP-0746542-A1 THERAPEUTIC BENZONITRILES THE WELLCOME FOUNDATION LIMITED (GB) 1996-12-11 EP disclosed
WO-1995023133-A1 THERAPEUTIC BENZONITRILES THE WELLCOME FOUNDATION LIMITED (GB) 1995-08-31 WO disclosed
WO-1995023134-A1 THERAPEUTIC BENZONITRILES THE WELLCOME FOUNDATION LIMITED (GB) 1995-08-31 WO disclosed