Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 0.72 |
| ▸ | MMP2 | P08253 | 4/20 | 0.72 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046092 | 1.00 | MMP3 (0.72) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7042806 | 0.84 | MAPT (0.58) | MMP3MMP2MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8667454 | 0.84 | MAPT (0.58) | MMP3MMP2MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7045834 | 0.83 | MAPT (0.54) | MMP3MMP2MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL7048964 | 0.83 | MMP3 (0.55) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL9513813 | 0.75 | LMNA (0.78) | MAPTSMN1; SMN2LMNACYP1A2GAA | |
| SCHEMBL155771 | 0.75 | LMNA (0.78) | MAPTSMN1; SMN2LMNACYP1A2GAA | |
| SCHEMBL14672093 | 0.75 | MAPT (0.57) | MAPTSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL15866588 | 0.73 | LMNA (0.62) | LMNAMTNR1AMTNR1B | |
| SCHEMBL31032939 | 0.73 | LMNA (0.62) | LMNAMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |