Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657430 | 0.90 | PTGS2 (0.49) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8657037 | 0.89 | PTGES2 (0.47) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL6725730 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1KIF11 | |
| SCHEMBL8660173 | 0.85 | KIF11 (0.57) | PTGS2PTGS1ALOX5APFEN1KIF11 | |
| SCHEMBL8659133 | 0.85 | FABP4 (0.45) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8662914 | 0.84 | ALOX5AP (0.41) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8658257 | 0.84 | PTGS1 (0.41) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8657983 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8662806 | 0.83 | PTGES2 (0.64) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8660169 | 0.82 | ALOX5AP (0.48) | PTGS2PTGS1ALOX5APFEN1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | claimed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |