Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657255 | 0.90 | CA9 (0.44) | PTGS2PTGS1F10MAPT | |
| SCHEMBL8656787 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1GAAF10P2RX3 | |
| SCHEMBL8656219 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1F10ALOX5APFEN1 | |
| SCHEMBL8661261 | 0.89 | PTGS1 (0.40) | PTGS2PTGS1GAAF10P2RX3 | |
| SCHEMBL8661927 | 0.88 | PTGS2 (0.36) | PTGS2PTGS1GAAHSD17B10F10 | |
| SCHEMBL8660177 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1F10P2RX3HSP90AA1 | |
| SCHEMBL8656138 | 0.87 | PTGS2 (0.43) | PTGS2PTGS1F10KDM4EALDH1A1 | |
| SCHEMBL8657315 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1F10KDM4EALDH1A1 | |
| SCHEMBL8659763 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8662796 | 0.85 | POLB (0.41) | PTGS2PTGS1GAAF10P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |