Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662811 | 0.89 | PKM (0.46) | PKMALDH1A1LMNANPSR1MCOLN3 | |
| SCHEMBL8659120 | 0.83 | PKM (0.49) | PKMALDH1A1LMNAESR1L3MBTL1 | |
| SCHEMBL8660081 | 0.82 | PKM (0.50) | PKMALDH1A1LMNANPSR1ESR1 | |
| SCHEMBL8659626 | 0.81 | PKM (0.49) | PKMALDH1A1LMNANPSR1MCOLN3 | |
| SCHEMBL8662966 | 0.81 | PKM (0.49) | PKMALDH1A1LMNAMCOLN3ESR1 | |
| SCHEMBL8658102 | 0.81 | PKM (0.49) | PKMALDH1A1LMNAESR1L3MBTL1 | |
| SCHEMBL8659474 | 0.79 | PKM (0.50) | PKMALDH1A1LMNANPSR1ESR1 | |
| SCHEMBL8663371 | 0.79 | PKM (0.53) | PKMALDH1A1ESR1KMT2A | |
| SCHEMBL8659118 | 0.79 | PKM (0.53) | PKMALDH1A1ESR1KMT2AMAPT | |
| SCHEMBL8660463 | 0.78 | PKM (0.49) | PKMALDH1A1LMNAMCOLN3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |