SCHEMBL8660358

SCHEMBL8660358

C=CCN(N=O)c1c([N+](=O)[O-])cc(C)c(C)c1[N+](=O)[O-]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
ALDH1A1 P00352 4/20 0.34
MAPT P10636 4/20 0.34
TDP1 Q9NUW8 1/20 0.34
KDM4E B2RXH2 2/20 0.33
KMT2A Q03164 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
MEN1 O00255 1/20 0.32
TSHR P16473 1/20 0.32
LMNA P02545 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11318911 0.84 CYP1A2 (0.41) CYP1A2ALDH1A1MAPTTDP1KDM4E
SCHEMBL8661325 0.82 CYP1A2 (0.39) CYP1A2ALDH1A1MAPTTDP1KDM4E
SCHEMBL11524922 0.80 MAPT (0.41) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL8371130 0.79 VCAM1 (0.39) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL10792911 0.76 CYP1A2 (0.44) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL10815711 0.74 MAPK1 (0.50) ALDH1A1MAPTTDP1KDM4ETSHR
SCHEMBL31413507 0.73 CYP1A2 (0.38) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL7524966 0.73 CYP1A2 (0.38) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL11324222 0.73 ALDH1A1 (0.51) CYP1A2ALDH1A1MAPTTDP1KMT2A
SCHEMBL11321842 0.72 CYP1A2 (0.40) CYP1A2ALDH1A1MAPTTDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630883-B1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS (IL) 1998-09-16 EP disclosed
US-5602283-A Multi-stage process for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1997-02-11 US disclosed
US-5475148-A Process and intermediate to prepare N-alkyl-3,4-dialkyl-2,6-dinitro-anilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1995-12-12 US disclosed
EP-0630883-A1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1994-12-28 EP disclosed