Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88833 | 0.85 | — | — | |
| SCHEMBL29813261 | 0.85 | — | — | |
| SCHEMBL15971546 | 0.83 | DYRK1A (0.50) | DYRK1ANAMPTCYP3A4KDM4EALDH1A1 | |
| Isoquinoline SCHEMBL10682580 | 0.75 | DYRK1A (0.43) | DYRK1ACYP11B2CYP11B1CYP19A1NAMPT | |
| Benzofuran SCHEMBL20488656 | 0.71 | TSHR (0.46) | NPY5RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31692910 | 0.69 | ALDH1A1 (0.38) | DYRK1ACYP11B2CYP11B1CYP19A1NAMPT | |
| SCHEMBL10824 | 0.69 | — | — | |
| Benzofuran SCHEMBL11554408 | 0.67 | DYRK1A (0.50) | DYRK1ANAMPTALDH1A1 | |
| Isoquinoline SCHEMBL9777562 | 0.67 | SIGMAR1 (0.57) | CYP11B2CYP11B1CYP19A1SIGMAR1CHRNB2 | |
| SCHEMBL32685371 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770763-A | POLYARYLCYCLOBUTENES DERIVED FROM 3,6 FUNCTIONALIZED MONO AND DICYCLOBUTABENZENE | THE BOARD OF REGENTS OF THE UNIV. OF MICHIGAN (US) | 1998-06-23 | — | — | US | disclosed |
| US-5552508-A | Difunctional bitricyclodecatriene monomers | UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS (US) | 1996-09-03 | — | — | US | disclosed |
| US-5418312-A | Polymer properties | THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1995-05-23 | — | — | US | disclosed |
| US-5334752-A | Difunctionalized to be incorporated into polymers for compressive strength | THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF UNIVERSITY OF MICHIGAN (US) | 1994-08-02 | — | — | US | disclosed |
| WO-1994001388-A1 | CYCLOBUTABENZENE MONOMERS AND METHODS OF MAKING AND USING SAME | UNIVERSITY OF MICHIGAN (US) | 1994-01-20 | — | — | WO | disclosed |