SCHEMBL8660780

SCHEMBL8660780

Cc1ccc(Oc2c(C)cc(NC(=S)NC(=O)c3ccccc3Cl)c(C)c2Cl)c(Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.59
SMN1; SMN2 Q16637 6/20 0.59
GAA P10253 5/20 0.59
MAPT P10636 4/20 0.59
KMT2A Q03164 4/20 0.59
KDM4E B2RXH2 3/20 0.52
RAB9A P51151 8/20 0.48
NPC1 O15118 5/20 0.48
POLB P06746 1/20 0.48
HPGD P15428 1/20 0.44
EPHX1 P07099 1/20 0.44
LMNA P02545 1/20 0.44
HTT P42858 1/20 0.43
ALOX12 P18054 2/20 0.42
TP53 P04637 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8666493 0.91 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8660797 0.91 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL9132579 0.89 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8666779 0.89 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8655911 0.88 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8658825 0.86 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8663041 0.85 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8662621 0.85 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8660971 0.85 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2GAAMAPTKMT2A
SCHEMBL8658014 0.84 PYGL (0.52) ALDH1A1SMN1; SMN2GAAMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
US-4873264-A Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation RHONE-POULENC NEDERLANDS B.V. (NL) 1989-10-10 US disclosed
EP-0098158-B1 PESTICIDAL 1-(ALKYL-PHENOXYARYL)-3-BENZOYL UREAS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1987-11-19 EP disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
EP-0098158-A1 Pesticidal 1-(alkyl-phenoxyaryl)-3-benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1984-01-11 EP disclosed