Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 5/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.61 |
| ▸ | HTR1D | P28221 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KIF20A | O95235 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266559 | 0.88 | TRPM8 (0.65) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL24183187 | 0.88 | TRPM8 (0.74) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL29007183 | 0.86 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL29617411 | 0.86 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL8658847 | 0.84 | GPR84 (0.66) | TRPM8MAPTHTR1DHTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL8658852 | 0.83 | GPR84 (0.64) | TRPM8MAPTHTR1DHTR1AHTR1B | |
| SCHEMBL24183118 | 0.82 | TRPM8 (0.63) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL15955987 | 0.80 | TRPM8 (0.70) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL28100769 | 0.79 | TRPM8 (0.72) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL2007192 | 0.79 | TRPM8 (0.72) | TRPM8KDM4EMAPTLTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834493-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | GIL QUINTERO MYRNA (IT) | 1998-11-10 | — | — | US | disclosed |
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |