SCHEMBL8660787

SCHEMBL8660787

[CH2]C(CCl)Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.46
TAAR1 Q96RJ0 4/20 0.43
SLC6A2 P23975 2/20 0.43
SIGMAR1 Q99720 2/20 0.43
MAOA P21397 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
CYP2A6 P11509 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
CYP1A2 P05177 1/20 0.41
SLC18A2 Q05940 1/20 0.40
ANPEP P15144 1/20 0.40
CYP2D6 P10635 1/20 0.40
ALPI P09923 1/20 0.39
PKM P14618 1/20 0.39
PTGS1 P23219 1/20 0.39
XIAP P98170 1/20 0.39
SLC7A5 Q01650 1/20 0.39
TRPA1 O75762 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1287678 0.85 EPHX1 (0.55) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL523308 0.78 EPHX1 (0.48) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL5657750 0.76 EPHX1 (0.52) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL8780026 0.76 TRPA1 (0.54) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL1376582 0.76 TRPA1 (0.50) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL1007428 0.75 EPHX1 (0.50) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL1143687 0.75 EPHX1 (0.50) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL9078072 0.74 EPHX1 (0.44) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL3588912 0.74 EPHX1 (0.55) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL6685343 0.73 EPHX1 (0.48) EPHX1TAAR1SLC6A2SIGMAR1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5645752-A Thixotropic magnetorheological materials LORD CORPORATION (US) 1997-07-08 US claimed
EP-0667029-B1 THIXOTROPIC MAGNETORHEOLOGICAL MATERIALS LORD CORP (US) 1998-09-23 EP disclosed
US-5645752-A Thixotropic magnetorheological materials LORD CORPORATION (US) 1997-07-08 US disclosed
EP-0489693-B1 Charged asymmetric mosaic membranes ALIGENA AG (CH) 1995-10-11 EP disclosed
EP-0667029-A1 THIXOTROPIC MAGNETORHEOLOGICAL MATERIALS LORD CORPORATION (US) 1995-08-16 EP disclosed
EP-0667029-A4 THIXOTROPIC MAGNETORHEOLOGICAL MATERIALS. LORD CORP (US) 1995-06-13 EP disclosed
WO-1995004121-A1 HIGH STRENGTH, LOW CONDUCTIVITY ELECTRORHEOLOGICAL MATERIALS LORD CORPORATION (US) 1995-02-09 WO disclosed
WO-1994010693-A1 THIXOTROPIC MAGNETORHEOLOGICAL MATERIALS LORD CORPORATION (US) 1994-05-11 WO disclosed
US-5304307-A Semipermeable ALIGENA AG (CH) 1994-04-19 US disclosed
EP-0489693-A1 Charged asymmetric mosaic membranes ALIGENA AG (CH) 1992-06-10 EP disclosed