Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.63 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362301 | 0.86 | CHRNB2 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL14097068 | 0.85 | LCK (0.66) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL12549321 | 0.81 | LCK (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL23657484 | 0.81 | CHRNB2 (0.74) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL14082482 | 0.80 | DEGS1 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4LMNA | |
| SCHEMBL15045375 | 0.80 | GRM5 (0.76) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL14082289 | 0.78 | CHRNB2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL14082903 | 0.77 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4LCK | |
| SCHEMBL14082158 | 0.77 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL12549340 | 0.77 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053904-C | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 2000-06-28 | — | — | CN | disclosed |
| US-5843947-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5712294-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0684241-B1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-08-27 | — | — | EP | disclosed |
| CN-1121074-A | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 1996-04-24 | — | — | CN | disclosed |
| EP-0684241-A1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-11-29 | — | — | EP | disclosed |