Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097068 | 0.95 | LCK (0.66) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL12549340 | 0.86 | CHRNB2 (0.58) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3362301 | 0.82 | CHRNB2 (0.64) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8660822 | 0.81 | CHRNB2 (0.63) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15045375 | 0.80 | GRM5 (0.76) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30711612 | 0.78 | LCK (0.67) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4504096 | 0.78 | LCK (0.67) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23657484 | 0.77 | CHRNB2 (0.74) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL50044 | 0.77 | LCK (0.60) | LCKCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3424508 | 0.76 | ALDH1A1 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450318-B2 | Method to treat infections using anti-infective agents | K.U. LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2013-05-28 | — | — | US | disclosed |
| US-8450318-B2 | Method to treat infections using anti-infective agents | K.U. LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2013-05-28 | — | — | US | disclosed |
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | MAZIK, MONIKA (DE) | 2011-06-09 | — | — | US | disclosed |
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | MAZIK, MONIKA (DE) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | ICAM1, MANBA, ALG1 | LCK 1930/4885CHRNB2 4865/4885CHRNB4 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.