Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5002639 | 1.00 | NR1I2 (0.53) | NR1I2NPSR1RELAKCNH2MMP1 | |
| SCHEMBL20710724 | 0.89 | NR1I2 (0.46) | NR1I2NPSR1RELAKCNH2MMP1 | |
| SCHEMBL28409779 | 0.86 | MEN1 (0.51) | NR1I2RELAMMP1MMP3MMP9 | |
| SCHEMBL5936857 | 0.83 | LCK (0.49) | NR1I2MMP1MMP9MAOAMAOB | |
| SCHEMBL28412694 | 0.83 | TDP1 (0.43) | NR1I2RELAMEN1KMT2AKDM4E | |
| SCHEMBL5667061 | 0.82 | GSK3B (0.53) | RELAMAOBNPC1 | |
| SCHEMBL10262188 | 0.82 | GSK3B (0.53) | RELAMAOBNPC1 | |
| SCHEMBL4821198 | 0.82 | NPSR1 (0.36) | NR1I2NPSR1RELAKCNH2MMP1 | |
| SCHEMBL8922929 | 0.82 | APP (0.39) | NR1I2NPSR1CYP1A2CYP3A4LMNA | |
| SCHEMBL8922931 | 0.82 | APP (0.39) | NR1I2NPSR1CYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198923-B2 | Phosphate management with small molecules | Opko Ireland Global Holdings, Ltd. (KY) | 2015-12-01 | — | — | US | disclosed |
| US-9198923-B2 | Phosphate management with small molecules | Opko Ireland Global Holdings, Ltd. (KY) | 2015-12-01 | — | — | US | disclosed |
| US-20120028926-A1 | Phosphate Management with Small Molecules | CYTOCHROMA INC. (CA) | 2012-02-02 | — | — | US | disclosed |
| US-20120028926-A1 | Phosphate Management with Small Molecules | CYTOCHROMA INC. (CA) | 2012-02-02 | — | — | US | disclosed |
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | THERAPHARM GMBH (CH) | 2008-12-18 | — | — | US | disclosed |
| US-20070155975-A1 | Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-07-05 | — | — | US | disclosed |
| US-5852198-A | Wittig reagents and method for preparing α,β-unsaturated phosphonates | MEDICHEM RESEARCH, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1997036909-A1 | WITTIG REAGENTS AND METHOD FOR PREPARING α,β-UNSATURATED PHOSPHONATES | MEDICHEM RESEARCH, INC. (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155975-A1 | Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts | OXER1, OSTC, OXSR1 | NR1I2 2168/4885NPSR1 1364/4885RELA 2389/4885 |
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | POLI, PARP1, DHPS | NR1I2 3695/4885NPSR1 2464/4885RELA 1886/4885 |
| US-20120028926-A1 | Phosphate Management with Small Molecules | SLC34A2, PHPT1, SLC34A3 | NR1I2 3199/4885NPSR1 2039/4885RELA 3366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.