SCHEMBL8661801

SCHEMBL8661801

O=C(O)c1cc(S(=O)(=O)C(F)(F)C(F)F)c(-c2ccc(Cl)cc2)[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.39
CA12 O43570 1/20 0.37
ALPL P05186 1/20 0.37
CHRNA7 P36544 1/20 0.36
F7 P08709 1/20 0.36
F3 P13726 1/20 0.36
MAPK14 Q16539 1/20 0.36
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34
BLM P54132 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM1A O60341 1/20 0.34
RHEB Q15382 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8665554 0.83 ALPL (0.45) ALPLCHRNA7KDM4EMEN1LMNA
SCHEMBL8663667 0.72 NOTUM (0.38) NOTUMCA12ALPLCHRNA7F7
SCHEMBL8661809 0.70 NOTUM (0.43) NOTUMCA12ALPLF7F3
SCHEMBL8662138 0.70 NOTUM (0.43) NOTUMCA12ALPLF7F3
SCHEMBL8666601 0.69 PTGS2 (0.40) CHRNA7KDM4EMEN1LMNAHPGD
SCHEMBL8665046 0.68 PTGS2 (0.32) MAPTNPSR1L3MBTL1PTGS2PTGS1
SCHEMBL11420549 0.68 PTGS1 (0.55) MAPK14HPGDMAPTNPSR1L3MBTL1
SCHEMBL8663128 0.68 KDM4E (0.35) KDM4EMEN1LMNAHPGDKMT2A
SCHEMBL8779966 0.68 PTGS2 (0.35) CHRNA7KDM4EMEN1LMNAHPGD
SCHEMBL8663058 0.68 PTGS2 (0.39) MAPK14PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed