Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 7/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570350 | 0.79 | MAPT (0.37) | HTR2BALDH1A1 | |
| SCHEMBL9765072 | 0.77 | ABCB1 (0.34) | — | |
| SCHEMBL9443650 | 0.76 | LMNA (0.35) | AHRPBRM1BACE1LMNAMAPK1 | |
| SCHEMBL9872032 | 0.74 | KDM4E (0.39) | AKR1B1 | |
| SCHEMBL3894061 | 0.74 | KCNE1 (0.35) | LMNAHTR2BALDH1A1NPSR1HTT | |
| Arsenic SCHEMBL8675880 | 0.73 | LMNA (0.34) | LMNAHTR2BNPSR1HTTTSHR | |
| SCHEMBL9141916 | 0.71 | HTR2A (0.36) | AHRLMNAMAPK1HTR2BHTR2A | |
| SCHEMBL23362474 | 0.70 | AHR (0.36) | AHRPBRM1BACE1LMNAMAPK1 | |
| SCHEMBL11000607 | 0.70 | KCNE1 (0.37) | AHRLMNAMAPK1PGRALDH1A1 | |
| SCHEMBL29804528 | 0.70 | AHR (0.36) | AHRPBRM1BACE1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876330-A1 | ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019052-A1 | ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-29 | — | — | WO | disclosed |