Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660376 | 0.86 | RIPK1 (0.37) | PIK3CDRIPK1MEN1KMT2ACES1 | |
| SCHEMBL8662712 | 0.84 | RIPK1 (0.38) | PIK3CDRIPK1MEN1KMT2ACES1 | |
| SCHEMBL6858149 | 0.83 | OPRK1 (0.38) | PIK3CDRIPK1MEN1KMT2A | |
| SCHEMBL8659654 | 0.81 | RIPK1 (0.36) | PIK3CDRIPK1MEN1KMT2A | |
| SCHEMBL8662813 | 0.80 | KMT2A (0.36) | PIK3CDRIPK1MEN1KMT2A | |
| SCHEMBL8661346 | 0.80 | RIPK1 (0.31) | PIK3CDRIPK1 | |
| SCHEMBL8662488 | 0.79 | MTNR1B (0.38) | RIPK1MEN1KMT2ACES1 | |
| SCHEMBL8660036 | 0.79 | RIPK1 (0.34) | PIK3CDRIPK1 | |
| SCHEMBL8809230 | 0.78 | PIK3CD (0.34) | PIK3CDRIPK1 | |
| SCHEMBL8662965 | 0.78 | PIK3CD (0.53) | PIK3CDRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |