Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660480 | 0.89 | ALOX5AP (0.41) | NPC1ALDH1A1RAB9AALOX5APFEN1 | |
| SCHEMBL8659722 | 0.86 | CA2 (0.45) | ALOX5APFEN1CA1CA2F10 | |
| SCHEMBL8661447 | 0.85 | PTGS2 (0.48) | ALOX5APFEN1CA1CA2F10 | |
| SCHEMBL8659726 | 0.84 | ALOX5AP (0.46) | ALOX5APFEN1CA1CA2 | |
| SCHEMBL8656122 | 0.84 | F10 (0.41) | RAB9AALOX5APFEN1CA1CA2 | |
| SCHEMBL8656822 | 0.84 | PTGS2 (0.51) | ALOX5APFEN1CA1CA2 | |
| SCHEMBL8663491 | 0.83 | ALOX5AP (0.41) | ALOX5APFEN1CA1CA2 | |
| SCHEMBL8659248 | 0.83 | DHODH (0.44) | ALDH1A1RAB9ASMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL8661969 | 0.83 | PTGES2 (0.50) | CA1CA2ADORA2AACLYAKR1C3 | |
| SCHEMBL8661443 | 0.83 | ALOX5AP (0.46) | ALOX5APFEN1CA1CA2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |