Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 5/20 | 0.39 |
| ▸ | CDK8 | P49336 | 5/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660649 | 0.84 | MAPT (0.44) | MAPTKDM4EMEN1KMT2AATM | |
| SCHEMBL8781554 | 0.75 | L3MBTL1 (0.36) | MAPTKDM4ECCNCCDK8CDK19 | |
| SCHEMBL8781556 | 0.75 | L3MBTL1 (0.36) | MAPTKDM4ECCNCCDK8CDK19 | |
| SCHEMBL8644915 | 0.71 | PIM1 (0.47) | MAPTKDM4EMEN1KMT2APIM1 | |
| SCHEMBL15245773 | 0.70 | MAPT (0.58) | MAPTKDM4EMEN1KMT2AATM | |
| SCHEMBL8424904 | 0.70 | PIM1 (0.46) | MAPTKDM4EKMT2APIM1 | |
| SCHEMBL28969558 | 0.69 | MAPT (0.56) | MAPTKDM4EMEN1KMT2AATM | |
| SCHEMBL4619581 | 0.68 | MEN1 (0.64) | MAPTKDM4EMEN1KMT2AATM | |
| SCHEMBL8650036 | 0.68 | HTR1A (0.51) | MAPTKDM4EMEN1KMT2APIM1 | |
| SCHEMBL4619586 | 0.68 | MEN1 (0.64) | MAPTKDM4EMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807857-A | Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists | MERCK SHARP & DOHME LTD. (GB) | 1998-09-15 | — | — | US | disclosed |