Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796420 | 0.86 | FABP5 (0.37) | KMT2AOPRD1MDM4TP53MDM2 | |
| SCHEMBL6798554 | 0.86 | FABP5 (0.37) | KMT2AOPRD1MDM4TP53MDM2 | |
| SCHEMBL31400184 | 0.76 | KMT2A (0.45) | KMT2AOPRD1MDM4TP53TLR2 | |
| SCHEMBL8659654 | 0.74 | RIPK1 (0.36) | KMT2A | |
| SCHEMBL8729229 | 0.74 | LMNA (0.39) | KMT2AOPRD1MDM4TP53 | |
| SCHEMBL6853795 | 0.74 | LMNA (0.39) | KMT2AOPRD1MDM4TP53 | |
| SCHEMBL8729183 | 0.74 | LMNA (0.39) | KMT2AOPRD1MDM4TP53 | |
| SCHEMBL8660036 | 0.72 | RIPK1 (0.34) | EPHX2 | |
| SCHEMBL29855170 | 0.72 | KMT2A (0.61) | KMT2AOPRD1MDM4TP53EPHX2 | |
| SCHEMBL6856330 | 0.71 | FABP5 (0.33) | MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |