Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662073 | 0.85 | CYP3A4 (0.49) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL6032861 | 0.84 | KMT2A (0.63) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL11021065 | 0.81 | KMT2A (0.53) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL8666034 | 0.80 | KMT2A (0.50) | KMT2AMEN1POLBGAAL3MBTL1 | |
| SCHEMBL8714576 | 0.79 | KMT2A (0.47) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL8698116 | 0.77 | KMT2A (0.52) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL8663765 | 0.76 | CYP3A4 (0.46) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL8666082 | 0.75 | KMT2A (0.54) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL8663972 | 0.74 | IDH1 (0.40) | KMT2AMEN1CYP3A4POLBGAA | |
| SCHEMBL11024739 | 0.72 | KMT2A (0.45) | KMT2AMEN1CYP3A4POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | claimed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | claimed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |