Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22921234 | 0.75 | ENPP2 (0.35) | MEN1KMT2A | |
| SCHEMBL8663397 | 0.74 | KMT2A (0.53) | POLBMEN1GAAKMT2ACYP3A4 | |
| SCHEMBL8663765 | 0.71 | CYP3A4 (0.46) | POLBMEN1GAAKMT2ACYP3A4 | |
| SCHEMBL8055227 | 0.70 | MEN1 (0.46) | POLBMEN1GAAKMT2AHSD11B1 | |
| SCHEMBL8032553 | 0.70 | MEN1 (0.46) | POLBMEN1GAAKMT2AHSD11B1 | |
| SCHEMBL8070504 | 0.69 | HSD11B1 (0.37) | HSD11B1USP1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12913657 | 0.69 | RIPK3 (0.40) | POLBMEN1GAAKMT2AHSD11B1 | |
| SCHEMBL8714576 | 0.66 | KMT2A (0.47) | POLBMEN1GAAKMT2ACYP3A4 | |
| SCHEMBL8054712 | 0.66 | HPGD (0.41) | GAAHSD11B1USP1 | |
| SCHEMBL8063312 | 0.64 | USP1 (0.39) | POLBMEN1GAAKMT2AUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | claimed |
| US-5783707-A | ANTICHOLESTEROL AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-07-21 | — | — | US | claimed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | claimed |
| US-5783707-A | ANTICHOLESTEROL AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-07-21 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |