SCHEMBL8663489

SCHEMBL8663489

Cc1cc(-c2c(F)c(F)c(F)c(F)c2NS(=O)(=O)c2ccccc2)cc(C)c1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYTH2 Q99418 3/20 0.54
FFAR4 Q5NUL3 3/20 0.53
KAT6A Q92794 5/20 0.50
KAT7 O95251 2/20 0.50
KAT6B Q8WYB5 1/20 0.50
KAT5 Q92993 1/20 0.50
METAP2 P50579 1/20 0.48
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
KMT2A Q03164 1/20 0.46
TSHR P16473 2/20 0.44
MCL1 Q07820 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
PKM P14618 1/20 0.44
ALOX15 P16050 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8661428 0.94 CYTH2 (0.54) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8657915 0.92 CYTH2 (0.51) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8656948 0.91 CYTH2 (0.50) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8656815 0.89 CYTH2 (0.51) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8660475 0.89 FFAR4 (0.56) CYTH2FFAR4METAP2TSHRMCL1
SCHEMBL8661075 0.88 CYTH2 (0.48) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8659214 0.88 CYTH2 (0.48) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8663500 0.88 CYTH2 (0.50) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8657865 0.87 CYTH2 (0.49) CYTH2FFAR4KAT6AKAT7KAT6B
SCHEMBL8660183 0.87 CYTH2 (0.48) CYTH2FFAR4KAT6AMETAP2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739166-A ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT G.D. SEARLE & CO. (US) 1998-04-14 US disclosed