SCHEMBL8664038

SCHEMBL8664038

FC(F)(F)Sc1cc(C(F)(F)F)[nH]c1-c1ccc(Cl)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
LMNA P02545 2/20 0.34
GLA P06280 2/20 0.34
GAA P10253 2/20 0.34
HTT P42858 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MEN1 O00255 1/20 0.34
HPGD P15428 1/20 0.34
CRHBP P24387 1/20 0.34
KMT2A Q03164 1/20 0.34
CRHR2 Q13324 1/20 0.34
GCGR P47871 5/20 0.33
MAPK14 Q16539 4/20 0.33
HSD17B10 Q99714 1/20 0.33
TNF P01375 1/20 0.32
NOD1 Q9Y239 1/20 0.32
PTGS1 P23219 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7784864 0.83 MEN1 (0.42) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL7782884 0.79 MAPT (0.39) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL8662138 0.78 NOTUM (0.43) KDM4ELMNAMEN1HPGDKMT2A
SCHEMBL9015117 0.76 GCGR (0.50) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL8798565 0.76 KDM4E (0.43) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL7778163 0.76 CHEK2 (0.36) KDM4EMAPTMEN1KMT2AGCGR
SCHEMBL29172448 0.75 GCGR (0.38) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL8665030 0.75 IKBKB (0.32) MAPTNPSR1LMNAL3MBTL1
SCHEMBL8663653 0.74 MAPT (0.46) KDM4EMAPTALDH1A1NPSR1LMNA
SCHEMBL7783637 0.72 PDE7A (0.47) MAPTALDH1A1NPSR1LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed