SCHEMBL8664115

SCHEMBL8664115

FC(F)Sc1ccc(-c2ccc(Cl)cc2)[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GCGR P47871 3/20 0.46
MAPT P10636 4/20 0.39
TRPM8 Q7Z2W7 1/20 0.38
POLB P06746 3/20 0.37
RAB9A P51151 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
NPC1 O15118 2/20 0.37
MAPK1 P28482 1/20 0.37
GFER P55789 1/20 0.37
ALDH1A1 P00352 4/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
MKNK1 Q9BUB5 1/20 0.36
MKNK2 Q9HBH9 1/20 0.36
IDO1 P14902 1/20 0.36
PPARG P37231 1/20 0.36
NCOA2 Q15596 1/20 0.36
NCOA1 Q15788 1/20 0.36
PTPN11 Q06124 1/20 0.35
KDM4E B2RXH2 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8662106 0.75 GCGR (0.46) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9254439 0.75 GCGR (0.46) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL8666609 0.65 GCGR (0.33) GCGRMAPTKDM4ECCNB2CDK1
SCHEMBL5272526 0.65 GCGR (0.55) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL7784928 0.64 GCGR (0.50) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL22734815 0.64 GCGR (0.50) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9052445 0.61 MKNK1 (0.56) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL6187270 0.60 GCGR (0.50) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL6890851 0.59 KDM4E (0.68) GCGRMAPTRAB9ANPC1MAPK1
SCHEMBL5674033 0.58 NOTUM (0.67) GCGRMAPTPOLBRAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed