Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17686758 | 0.84 | AXL (0.54) | MKNK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL31466033 | 0.80 | PDPK1 (0.42) | MKNK1RAB9AMAPTPOLBGCGR | |
| SCHEMBL17686763 | 0.79 | TNIK (0.44) | NPC1RAB9AKMT2APOLBTNIK | |
| SCHEMBL17686764 | 0.74 | NOTUM (0.44) | RAB9ANOTUM | |
| SCHEMBL1531261 | 0.72 | MKNK1 (0.61) | MKNK1MKNK2TRPM8LTA4HNPC1 | |
| SCHEMBL27216948 | 0.72 | MKNK1 (0.61) | MKNK1MKNK2TRPM8LTA4HNPC1 | |
| SCHEMBL3070625 | 0.72 | TRPM8 (0.62) | MKNK1MKNK2TRPM8LTA4HNPC1 | |
| SCHEMBL5630086 | 0.72 | MKNK1 (1.00) | MKNK1MKNK2TRPM8LTA4HNPC1 | |
| SCHEMBL17627136 | 0.70 | IKBKB (0.41) | RAB9ASMN1; SMN2TNIKKDM4ENOTUM | |
| SCHEMBL9049682 | 0.70 | MAPT (0.66) | MKNK1MKNK2TRPM8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731795-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |