SCHEMBL9254439

SCHEMBL9254439

FC(F)(Cl)Sc1ccc(-c2ccc(Cl)cc2)[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.46
MAPT P10636 4/20 0.39
TRPM8 Q7Z2W7 1/20 0.38
POLB P06746 3/20 0.37
RAB9A P51151 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
NPC1 O15118 2/20 0.37
SCN2A Q99250 1/20 0.37
MAPK1 P28482 1/20 0.37
GFER P55789 1/20 0.37
ALDH1A1 P00352 5/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
KDM4E B2RXH2 3/20 0.36
HPGD P15428 2/20 0.36
GAA P10253 2/20 0.36
LMNA P02545 1/20 0.36
GLA P06280 1/20 0.36
CRHBP P24387 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8662106 0.89 GCGR (0.46) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9253366 0.80 SCN2A (0.44) GCGRSCN2AALDH1A1MEN1KMT2A
SCHEMBL8664115 0.75 GCGR (0.46) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9253902 0.72 ALDH1A1 (0.41) GCGRSCN2AALDH1A1MEN1KMT2A
SCHEMBL7784928 0.72 GCGR (0.50) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL26586294 0.68 GCGR (0.42) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9254319 0.66 GCGR (0.43) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL9254221 0.65 GCGR (0.32) GCGRMAPTKDM4E
SCHEMBL5272526 0.65 GCGR (0.55) GCGRMAPTTRPM8POLBRAB9A
SCHEMBL28260000 0.64 GCGR (0.50) GCGRMAPTTRPM8POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5378724-A Insecticide. miticide, nematocide BAYER AKTIENGESELLSCHAFT (DE) 1995-01-03 US disclosed
EP-0591806-A1 Substituted 2-arylpyrroles BAYER AG (DE) 1994-04-13 EP disclosed