Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381777 | 0.86 | LMNA (0.50) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL29100487 | 0.86 | MAPT (0.54) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL4461219 | 0.86 | SRC (0.57) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL722399 | 0.86 | KDM4E (0.50) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL7261599 | 0.86 | MAPT (0.54) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL28128326 | 0.83 | MAPT (0.51) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL16401062 | 0.82 | LMNA (0.52) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL15265304 | 0.80 | MAPT (0.49) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL28118327 | 0.80 | SRC (0.52) | KDM4EMAPTLMNAMETAP2METAP1 | |
| SCHEMBL4386263 | 0.78 | KDM4E (0.72) | KDM4EMAPTLMNAMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852233-A1 | CYCLOSPORIN PHOSPHATE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-07-08 | — | — | EP | disclosed |