Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727200 | 0.84 | TRPV4 (0.38) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL7202604 | 0.84 | TRPV4 (0.38) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL7768183 | 0.82 | TRPV4 (0.36) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL8049906 | 0.82 | TRPV4 (0.41) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL9489852 | 0.82 | TRPV4 (0.42) | TRPV4KHKCYP11B2CYP11B1EGLN2 | |
| SCHEMBL9447114 | 0.80 | TRPV4 (0.35) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL30107963 | 0.79 | TRPV4 (0.38) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL9693924 | 0.79 | GPR35 (0.41) | TRPV4KHKCYP11B2ALDH1A1AR | |
| SCHEMBL7922013 | 0.79 | TRPV4 (0.38) | TRPV4KHKCYP11B2MAPK1ALDH1A1 | |
| SCHEMBL16122643 | 0.77 | GRM5 (0.42) | TRPV4KHKCYP11B2ALDH1A1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635486-B1 | Process for the preparation of fluorobenzonitriles | CLARIANT GMBH (DE) | 1998-12-09 | — | — | EP | disclosed |
| US-5777181-A | 2, 4, 5-trihalogeno- and 2, 3, 4, 5-tetrahalogenobenzene derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5565614-A | FLUORINATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-10-15 | — | — | US | disclosed |
| US-5530158-A | CHEMICAL INTERMEDIATE FOR ANTIBACTERIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-06-25 | — | — | US | disclosed |
| US-5466859-A | Process for preparing fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-14 | — | — | US | disclosed |
| EP-0635486-A2 | Process for the preparation of fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-01-25 | — | — | EP | disclosed |
| US-5362909-A | Two stage fluorination | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-08 | — | — | US | disclosed |
| US-5200548-A | Intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-06 | — | — | US | disclosed |
| US-5072038-A | Chemical intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-10 | — | — | US | disclosed |
| CN-1013370-B | Process for preparing derivatives of 2, 4, 5-trihalobenzenes and 2, 3, 4, 5-tetrahalobenzenes | BAYER AG (DE) | 1991-07-31 | — | — | CN | disclosed |
| EP-0164619-B1 | 2,4,5-TRIHALO OR 2,3,4,5-TETRAHALO BENZENE DERIVATIVES AND PROCESS FOR PRODUCING THEM | BAYER AG (DE) | 1988-10-12 | — | — | EP | disclosed |
| CN-85101737-A | Preparation 2,4,5-trihalogenated benzene and 2,3,4, the derivative method of 5-tetrahalogeno-benzene | — | 1987-01-31 | — | — | CN | disclosed |
| EP-0164619-A1 | 2,4,5-Trihalo or 2,3,4,5-tetrahalo benzene derivatives and process for producing them | BAYER AG (DE) | 1985-12-18 | — | — | EP | disclosed |