Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576999 | 0.86 | KCNH2 (0.42) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8572364 | 0.86 | KMT2A (0.44) | ALDH1A1KMT2AMEN1TRPA1NR1I2 | |
| SCHEMBL8573402 | 0.81 | KMT2A (0.43) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8572544 | 0.81 | KMT2A (0.46) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8574338 | 0.80 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8574021 | 0.77 | TRPA1 (0.40) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8577093 | 0.76 | POLB (0.45) | ALDH1A1KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL8574961 | 0.76 | MAPT (0.41) | ALDH1A1KMT2AMEN1HPGDTRPA1 | |
| SCHEMBL8574333 | 0.75 | EGFR (0.41) | ALDH1A1KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL8574078 | 0.75 | MAPKAPK2 (0.42) | ALDH1A1KMT2AMEN1HPGDTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | disclosed |