SCHEMBL8574338

SCHEMBL8574338

CN(C)C1CCN(C2CC(Nc3ccc(F)c(Cl)c3)CC[N]2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HPGD P15428 3/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
USP2 O75604 1/20 0.36
HSP90AA1 P07900 1/20 0.36
PKM P14618 1/20 0.36
LMNA P02545 2/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
EGFR P00533 2/20 0.35
AXL P30530 1/20 0.35
ALOX12 P18054 1/20 0.34
ERBB2 P04626 1/20 0.34
HTT P42858 1/20 0.34
NPY5R Q15761 1/20 0.33
MALT1 Q9UDY8 1/20 0.33
TRPA1 O75762 1/20 0.33
WEE1 P30291 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8577103 0.87 KMT2A (0.40) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8574961 0.87 MAPT (0.41) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8573924 0.86 CDK2 (0.42) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8574333 0.86 EGFR (0.41) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8575750 0.86 MAPT (0.41) ALDH1A1HPGDMAPTLMNAKMT2A
SCHEMBL8576088 0.84 MAPKAPK2 (0.41) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8573986 0.84 LMNA (0.45) ALDH1A1LMNAKMT2AMEN1EGFR
SCHEMBL8664359 0.80 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8574967 0.79 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2HPGDGAAMAPT
SCHEMBL8577384 0.77 MALT1 (0.37) ALDH1A1SMN1; SMN2HPGDGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821240-A ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS DR. KARL THOMAE GMBH (DE) 1998-10-13 US disclosed