SCHEMBL8664533

SCHEMBL8664533

Nc1ccc2sc3ccc(N)cc3c(=O)c2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.52
NPC1 O15118 7/20 0.52
SMN1; SMN2 Q16637 6/20 0.52
MAPT P10636 5/20 0.52
GFER P55789 2/20 0.52
ALDH1A1 P00352 5/20 0.50
HPGD P15428 2/20 0.50
KDM4E B2RXH2 4/20 0.48
TDP1 Q9NUW8 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
PARP1 P09874 3/20 0.40
NOX4 Q9NPH5 2/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
NFKB1 P19838 2/20 0.36
NFKB2 Q00653 2/20 0.36
RELA Q04206 2/20 0.36
MAPK1 P28482 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16236532 0.92 RAB9A (0.58) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL31068657 0.90 KDM4E (0.64) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL1535323 0.90 KDM4E (0.64) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL15237050 0.89 ALDH1A1 (0.45) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL30340804 0.85 MAPT (0.58) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL3887754 0.85 MAPT (0.58) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL2435773 0.82 RAB9A (0.61) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL14021071 0.78 ALDH1A1 (0.79) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL3480951 0.77 MAPT (0.73) RAB9ANPC1SMN1; SMN2MAPTGFER
SCHEMBL31238914 0.77 MAPT (0.73) RAB9ANPC1SMN1; SMN2MAPTGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577245-B1 Photogenerating azo pigments XEROX CORP (US) 1998-12-02 EP claimed
US-5281503-A Multilayer element with disazo pigments and charge generating layer XEROX CORPORATION (US) 1994-01-25 US claimed
EP-0577245-A1 Photogenerating azo pigments XEROX CORPORATION (US) 1994-01-05 EP claimed
CN-111040160-A Thioxanthone polyimide and preparation method thereof 湖南工业大学 2020-04-21 CN disclosed
EP-0577245-B1 Photogenerating azo pigments XEROX CORP (US) 1998-12-02 EP disclosed
US-5281503-A Multilayer element with disazo pigments and charge generating layer XEROX CORPORATION (US) 1994-01-25 US disclosed
EP-0577245-A1 Photogenerating azo pigments XEROX CORPORATION (US) 1994-01-05 EP disclosed