SCHEMBL8665166

SCHEMBL8665166

CCc1ccccc1C1=C(NC(=O)C(C)C)C(=O)c2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 8/20 0.48
HSP90AB1 P08238 8/20 0.48
MAPT P10636 3/20 0.45
TDP2 O95551 1/20 0.44
PAX8 Q06710 1/20 0.44
HKDC1 Q2TB90 1/20 0.44
TLR9 Q9NR96 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
APAF1 O14727 1/20 0.43
NPC1 O15118 1/20 0.43
CASP3 P42574 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
MDM4 O15151 2/20 0.42
TP53 P04637 2/20 0.42
ALDH1A1 P00352 2/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8108755 0.88 HSP90AA1 (0.63) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8092798 0.86 MAPT (0.57) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8106236 0.84 FGFR1 (0.50) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8664759 0.84 HSP90AA1 (0.49) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8106589 0.84 TDP2 (0.66) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8102262 0.83 HSP90AA1 (0.65) HSP90AA1HSP90AB1MAPTALDH1A1MEN1
SCHEMBL8106472 0.82 DHODH (0.49) HSP90AA1HSP90AB1MAPTTDP2L3MBTL1
SCHEMBL8108751 0.81 TDP2 (0.56) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8102495 0.79 TDP2 (0.46) HSP90AA1HSP90AB1MAPTTDP2PAX8
SCHEMBL8108508 0.79 MAPT (0.43) HSP90AA1HSP90AB1MAPTTDP2PAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882706-A1 Cell adhesion inhibitors ELI LILLY AND COMPANY (US) 1998-12-09 EP disclosed