SCHEMBL8102262

SCHEMBL8102262

CC(C)C(=O)NC1=C(c2ccccc2)c2ccccc2C1=O

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.65
HSP90AB1 P08238 13/20 0.65
FGFR1 P11362 4/20 0.53
FGFR2 P21802 4/20 0.53
FGFR4 P22455 4/20 0.53
FGFR3 P22607 4/20 0.53
SRC P12931 2/20 0.53
CDC25A P30304 1/20 0.50
CDC25B P30305 1/20 0.50
CRHBP P24387 1/20 0.49
CRHR2 Q13324 1/20 0.49
ADORA1 P30542 1/20 0.48
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664759 0.86 HSP90AA1 (0.49) HSP90AA1HSP90AB1FGFR1FGFR2FGFR4
SCHEMBL8102615 0.85 HSP90AA1 (0.88) HSP90AA1HSP90AB1FGFR1FGFR2FGFR4
SCHEMBL8665166 0.83 HSP90AA1 (0.48) HSP90AA1HSP90AB1MEN1ALDH1A1MAPT
SCHEMBL8100343 0.81 HSP90AA1 (0.61) HSP90AA1HSP90AB1FGFR1FGFR2FGFR4
SCHEMBL8102319 0.80 TDP2 (0.68) HSP90AA1HSP90AB1FGFR1FGFR2FGFR4
SCHEMBL8106472 0.80 DHODH (0.49) HSP90AA1HSP90AB1MEN1ALDH1A1MAPT
SCHEMBL8102448 0.80 HSP90AA1 (0.47) HSP90AA1HSP90AB1MEN1ALDH1A1MAPT
SCHEMBL8100811 0.79 HSP90AA1 (0.46) HSP90AA1HSP90AB1CDC25ACDC25BMEN1
SCHEMBL16296838 0.79 HSP90AA1 (1.00) HSP90AA1HSP90AB1MAPT
SCHEMBL8102673 0.78 HSP90AA1 (0.57) HSP90AA1HSP90AB1FGFR1FGFR2FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6022884-A PROPHYLAXIS OR TREATMENT OF INFLAMMATION AMGEN INC. (US) 2000-02-08 US disclosed
US-6013674-A INDENONE AMIDE DERIVATIVES, USEFUL FOR FOR THE INHIBITION OF LEUKOCYTE ADHERENCE TO ENDOTHELIAL CELLS; USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, AS ARTHRITIS, ASTHAMA, PSORIASIS, RESPIRATORY DISTRESS SYNDROME, STROKE AND ULCER ELI LILLY AND COMPANY (US) 2000-01-11 US disclosed
EP-0882706-A1 Cell adhesion inhibitors ELI LILLY AND COMPANY (US) 1998-12-09 EP disclosed