Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409903 | 0.98 | SLC22A1 (0.42) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| SCHEMBL9409911 | 0.88 | SLC22A1 (0.52) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| Hydrochloric Acid SCHEMBL8959213 | 0.85 | KCNH2 (0.56) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| Hydrochloric Acid SCHEMBL8959268 | 0.82 | SLC22A1 (0.42) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| SCHEMBL8671617 | 0.82 | SLC22A1 (0.56) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| SCHEMBL8671957 | 0.82 | SLC22A1 (0.56) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| Bromide SCHEMBL10756434 | 0.81 | KCNH2 (0.56) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| Hydrochloric Acid SCHEMBL194044 | 0.80 | MEN1 (0.59) | SLC22A1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL8664739 | 0.80 | SLC22A1 (0.44) | PSMD14HSP90AA1MMP2MC4RRAD52 | |
| Hydrochloric Acid SCHEMBL27803298 | 0.78 | MEN1 (0.58) | SLC22A1MEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630884-B1 | Method and composition providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants | LUMIGEN INC (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5747499-A | CYCLOPENTAQUINAZOLINE COMPOUNDS CYCLOPENTAQUINAZOLINE COMPOUNDS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5650099-A | ARYL PHOSPHONIUM OR PHOSPHONIUM/AMMONIUM SURFACTANTS | LUMIGEN, INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5484556-A | AMMONIUM OR PHOSPHONIUM CATIONIC SURFACTANT | LUMIGEN, INC. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5451347-A | 1,2-dioxetans with ammonium or phosphonium compounds | LUMIGEN, INC. (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0630884-A2 | Method and composition providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants | LUMIGEN, INC. (US) | 1994-12-28 | — | — | EP | disclosed |