Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10756434 | 0.96 | KCNH2 (0.56) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| SCHEMBL9409911 | 0.88 | SLC22A1 (0.52) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL8665765 | 0.85 | PSMD14 (0.41) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| SCHEMBL9409903 | 0.82 | SLC22A1 (0.42) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL8959268 | 0.82 | SLC22A1 (0.42) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| SCHEMBL8671617 | 0.82 | SLC22A1 (0.56) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| SCHEMBL8671957 | 0.82 | SLC22A1 (0.56) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL194044 | 0.80 | MEN1 (0.59) | SMN1; SMN2HTTSLC22A1ALDH1A1MEN1 | |
| SCHEMBL8664739 | 0.80 | SLC22A1 (0.44) | KCNH2SMN1; SMN2PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL8923750 | 0.79 | KCNH2 (0.49) | KCNH2SMN1; SMN2LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545502-A | CONTAINING SPECIFIED QUATERNARY AMMONIUM SALT AS CHARGE CONTROL AGENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-08-13 | — | — | US | disclosed |
| EP-0602566-B1 | Electrostatic image-developing toner | MITSUBISHI CHEM CORP (JP) | 1996-07-31 | — | — | EP | disclosed |
| EP-0602566-A1 | Electrostatic image-developing toner | Mitsubishi Chemical Corporation (JP) | 1994-06-22 | — | — | EP | disclosed |