Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668413 | 0.91 | PPARD (0.43) | PLK1PPARDRARBTHRB | |
| SCHEMBL3486531 | 0.88 | RARB (0.54) | PLK1RARBTRPV1 | |
| SCHEMBL8671670 | 0.81 | HDAC1 (0.45) | PLK1PPARD | |
| SCHEMBL1835123 | 0.80 | TAAR1 (0.42) | PPARD | |
| SCHEMBL1833138 | 0.80 | FDPS (0.43) | PPARD | |
| SCHEMBL11795292 | 0.80 | MAOB (0.43) | PPARD | |
| SCHEMBL8658558 | 0.79 | CETP (0.45) | — | |
| SCHEMBL8668415 | 0.78 | ALDH1A1 (0.50) | PLK1PPARDRARB | |
| SCHEMBL9602529 | 0.76 | HRH1 (0.41) | PPARD | |
| SCHEMBL10726455 | 0.76 | CYP4A11 (0.54) | CYP4A11CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638581-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5480874-A | THIAZOLE AND IMIDAZOLE DERIVATIVES; ANTIHYPERLIPIDEMICS AND HYPOGLYCEMICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0638581-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-15 | — | — | EP | disclosed |