Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636710 | 0.89 | TDP1 (0.51) | TSHRRAB9ACASRSLC7A5LOXL2 | |
| SCHEMBL2458334 | 0.88 | KMT2A (0.46) | TSHRRAB9ALOXL2CYP4F2CYP4A11 | |
| SCHEMBL3340741 | 0.87 | GPR17 (0.50) | TSHRRAB9ACASRSLC7A5LOXL2 | |
| SCHEMBL4810030 | 0.86 | LOXL2 (0.50) | TSHRRAB9ACASRSLC7A5LOXL2 | |
| SCHEMBL1568650 | 0.86 | ADRB2 (0.54) | TSHRRAB9ALOXL2CYP4F2CYP4A11 | |
| SCHEMBL4407209 | 0.84 | TSHR (0.53) | TSHRRAB9APTGS1PTGS2CASR | |
| SCHEMBL30251598 | 0.84 | TSHR (0.64) | TSHRRAB9APPARAALDH1A1ROCK2 | |
| SCHEMBL866718 | 0.84 | TSHR (0.64) | TSHRRAB9APPARAALDH1A1ROCK2 | |
| SCHEMBL2650423 | 0.84 | TSHR (0.53) | TSHRRAB9APTGS1PTGS2CASR | |
| SCHEMBL4407205 | 0.84 | TSHR (0.53) | TSHRRAB9APTGS1PTGS2CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11766435-B2 | N3-substituted iminopyrimidinones as antimalarial agents | MERCK SHARP & DOHME LLC (US) | 2023-09-26 | — | — | US | disclosed |
| US-11766435-B2 | N3-substituted iminopyrimidinones as antimalarial agents | MERCK SHARP & DOHME LLC (US) | 2023-09-26 | — | — | US | disclosed |
| US-11766435-B2 | N3-substituted iminopyrimidinones as antimalarial agents | MERCK SHARP & DOHME LLC (US) | 2023-09-26 | — | — | US | disclosed |
| US-20200230140-A1 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2020-07-23 | — | — | US | disclosed |
| US-20200230140-A1 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2020-07-23 | — | — | US | disclosed |
| EP-3416647-A2 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | Merck Sharp & Dohme Corp. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142825-A2 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017142825-A2 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | WO | disclosed |
| EP-2718280-B1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMA SPA (IT) | 2015-09-16 | — | — | EP | disclosed |
| EP-2718280-B1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMA SPA (IT) | 2015-09-16 | — | — | EP | disclosed |
| WO-2012168359-A1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012168359-A1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-12-13 | — | — | WO | disclosed |
| US-20100160424-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-06-24 | — | — | US | disclosed |
| US-20100160424-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-06-24 | — | — | US | disclosed |
| US-20100160424-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-06-24 | — | — | US | disclosed |
| EP-2170815-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156817-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008156817-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| US-6069149-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | TERUMO KABUSHIKI KAISHA (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0894797-A1 | NOVEL AMIDE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | TERUMO KABUSHIKI KAISHA (JP) | 1999-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200230140-A1 | N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS | CTSL, ANPEP, PRSS1 | TSHR 3988/4885RAB9A 2450/4885PTGS1 2147/4885 |
| US-11766435-B2 | N3-substituted iminopyrimidinones as antimalarial agents | CTSL, ANPEP, PRSS1 | TSHR 3988/4885RAB9A 2450/4885PTGS1 2147/4885 |
| US-20100160424-A1 | RENIN INHIBITORS | ACE, REN, DNPEP | TSHR 3858/4885RAB9A 458/4885PTGS1 2122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.