Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061656 | 0.83 | HRH3 (1.00) | HRH3MEN1KMT2ASIGMAR1SLC6A3 | |
| SCHEMBL593755 | 0.81 | LMNA (0.50) | HRH3MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL2008758 | 0.76 | CXCR4 (0.56) | HRH3MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL22800939 | 0.75 | SLC6A4 (0.49) | HRH3MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL27423721 | 0.74 | SIGMAR1 (0.44) | HRH3MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL29193452 | 0.73 | HRH3 (0.70) | HRH3SIGMAR1SLC6A4KCNH2SLC6A2 | |
| SCHEMBL30853791 | 0.71 | HRH3 (0.73) | HRH3MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL12879708 | 0.71 | HRH3 (0.73) | HRH3MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL20676128 | 0.70 | HRH3 (0.71) | HRH3MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL9321242 | 0.69 | SLC6A4 (0.50) | HRH3SIGMAR1SLC6A4KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |