SCHEMBL8667367

SCHEMBL8667367

COc1ccccc1C1(C2(c3ccccc3OC)N=C(c3ccc(C(=O)Oc4ccccc4)cc3)C(c3ccc(C(=O)Oc4ccccc4)cc3)=N2)N=C(c2ccc(C(=O)Oc3ccccc3)cc2)C(c2ccc(C(=O)Oc3ccccc3)cc2)=N1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.46
MAPT P10636 6/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 4/20 0.40
MEN1 O00255 2/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
POLB P06746 1/20 0.40
PRSS1 P07477 2/20 0.40
ACR P10323 2/20 0.40
PARP10 Q53GL7 1/20 0.40
TMPRSS15 P98073 1/20 0.39
TDP1 Q9NUW8 2/20 0.39
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2494165 0.85 MAPT (0.42) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL2492052 0.83 MAPT (0.41) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL8665403 0.83 MAPT (0.48) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL2496334 0.82 PARP10 (0.41) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL2495232 0.82 PARP10 (0.41) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL2497219 0.81 PARP10 (0.40) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL152089 0.80 CA12 (0.41) KMT2ASMN1; SMN2ALDH1A1KDM4EGAA
SCHEMBL8665764 0.79 MYC (0.47) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1
SCHEMBL2494847 0.76 KMT2A (0.41) KMT2AMAPTALDH1A1MEN1KDM4E
SCHEMBL25251817 0.76 SYK (0.39) KMT2AMAPTSMN1; SMN2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5792589-A ORGANIC BINDER; OPTICALLY CROSSLINKABLE COMPOUND; RADICAL-GENERATING AGENT: 2,4,5-TRIARYL IMIDAZOLE DIMER, AMINO-GROUP CONTAINING BENZOPHENONE PHOTOSENSITIZER, A THIOL COMPOUND JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-08-11 US disclosed