SCHEMBL8667666

SCHEMBL8667666

COC(=O)Cc1ccc(C(NC(=O)OC(C)(C)C)C(=O)O)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 2/20 0.49
CTSK P43235 2/20 0.49
ATM Q13315 2/20 0.46
PPARA Q07869 9/20 0.44
PPARG P37231 8/20 0.44
CYP4F2 P78329 1/20 0.43
CYP4A11 Q02928 1/20 0.43
PPARD Q03181 2/20 0.42
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TP53 P04637 1/20 0.41
PKM P14618 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
AGTR1 P30556 1/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8667675 0.90 CTSS (0.46) CTSSCTSKATMPPARAPPARG
SCHEMBL11353294 0.85 CTSS (0.52) CTSSCTSKATMPPARAPPARG
SCHEMBL4890128 0.82 CTSS (0.46) CTSSCTSKATMPPARAPPARG
SCHEMBL4684444 0.82 CTSS (0.50) CTSSCTSKATMPPARAPPARG
SCHEMBL4684445 0.82 CTSS (0.50) CTSSCTSKATMPPARAPPARG
SCHEMBL8667664 0.82 CTSS (0.49) CTSSCTSKATMPPARAPPARG
SCHEMBL18867238 0.81 CTSK (0.46) CTSSCTSKATMPPARAPPARG
SCHEMBL844432 0.81 ATM (0.56) CTSSCTSKATMPPARAPPARG
SCHEMBL844431 0.81 ATM (0.56) CTSSCTSKATMPPARAPPARG
SCHEMBL3217896 0.81 ATM (0.56) CTSSCTSKATMPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5747499-A CYCLOPENTAQUINAZOLINE COMPOUNDS CYCLOPENTAQUINAZOLINE COMPOUNDS BRITISH TECHNOLOGY GROUP LIMITED (GB) 1998-05-05 US disclosed
EP-0758328-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BTG INTERNATIONAL LIMITED (GB) 1997-02-19 EP disclosed
WO-1995030673-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BRITISH TECHNOLOGY GROUP LIMITED (GB) 1995-11-16 WO disclosed