Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118900 | 0.90 | NQO2 (0.46) | OPRM1OPRK1OPRL1MAPTNQO2 | |
| SCHEMBL12083228 | 0.90 | NQO2 (0.46) | OPRM1OPRK1OPRL1MAPTNQO2 | |
| SCHEMBL8670268 | 0.80 | OPRM1 (0.50) | OPRM1OPRK1OPRL1MAPTNQO2 | |
| SCHEMBL8665499 | 0.77 | MAPT (0.45) | OPRM1OPRK1OPRL1MAPTKDM4E | |
| SCHEMBL9603210 | 0.77 | MAPT (0.45) | OPRM1OPRK1OPRL1MAPTKDM4E | |
| SCHEMBL3050512 | 0.77 | MEN1 (0.51) | OPRM1OPRK1OPRL1MAPTNQO2 | |
| SCHEMBL9100828 | 0.77 | MEN1 (0.37) | OPRM1OPRK1MAPTNQO2KDM4E | |
| SCHEMBL8672902 | 0.72 | MGLL (0.38) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12469978 | 0.72 | OPRM1 (0.65) | OPRM1OPRK1OPRL1MAPTNQO2 | |
| SCHEMBL28502116 | 0.71 | NQO2 (0.51) | OPRM1OPRK1OPRL1MAPTNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | claimed |
| US-5726323-A | COMPOUNDS USEFUL FOR ALLEVIATING MEMORY DYSFUNCTIONS | HOECHST MARION ROUSSEL, INC. | 1998-03-10 | — | — | US | disclosed |
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0484573-B1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |
| US-5081117-A | Treatment of memory dysfunctions such as in Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-14 | — | — | US | disclosed |