Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CBX7 | O95931 | 2/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665499 | 1.00 | MAPT (0.45) | MAPTLMNAKDM4EHCRTR1RAD52 | |
| SCHEMBL28250863 | 0.80 | MAPT (0.50) | MAPTLMNAKDM4EHCRTR1RAD52 | |
| SCHEMBL29184031 | 0.79 | HTR7 (0.49) | MAPTLMNAKDM4EHCRTR1RAD52 | |
| SCHEMBL28496150 | 0.79 | RAD52 (0.51) | MAPTLMNAKDM4EHCRTR1RAD52 | |
| SCHEMBL21666068 | 0.78 | MAPT (0.47) | MAPTLMNAKDM4EHCRTR1RAD52 | |
| SCHEMBL9118900 | 0.77 | NQO2 (0.46) | MAPTLMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL12083228 | 0.77 | NQO2 (0.46) | MAPTLMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL8667995 | 0.77 | OPRM1 (0.44) | MAPTLMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL12083153 | 0.77 | GAA (0.38) | MAPTLMNARAD52ALDH1A1PKM | |
| SCHEMBL28737050 | 0.76 | MAPT (0.46) | MAPTLMNAKDM4EHCRTR1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274117-A | Heating a racemic oxindole, a halogenated acetonitrile and a catalyst to form the alkylated oxindole | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0438796-A2 | Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-07-31 | — | — | EP | disclosed |