SCHEMBL8668528

SCHEMBL8668528

O=[N+]([O-])c1ccc2c([N+](=O)[O-])cccc2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.66
TDP1 Q9NUW8 3/20 0.66
ALDH1A1 P00352 7/20 0.63
LMNA P02545 1/20 0.52
GPR35 Q9HC97 2/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HIF1A Q16665 1/20 0.47
HPRT1 P00492 1/20 0.46
CASP6 P55212 1/20 0.46
MEN1 O00255 2/20 0.46
MAPT P10636 2/20 0.46
KMT2A Q03164 2/20 0.46
TXNRD1 Q16881 1/20 0.46
TXNRD3 Q86VQ6 1/20 0.46
TXNRD2 Q9NNW7 1/20 0.46
KDM4E B2RXH2 1/20 0.46
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28257118 0.86 TDP1 (0.54) TSHRTDP1ALDH1A1LMNAGPR35
SCHEMBL28158961 0.86 ALDH1A1 (0.71) TSHRTDP1ALDH1A1LMNAHPRT1
SCHEMBL28197400 0.86 TDP1 (0.54) TSHRTDP1ALDH1A1LMNAGPR35
SCHEMBL187061 0.85 ALDH1A1 (0.63) TSHRTDP1ALDH1A1LMNAGPR35
SCHEMBL28257786 0.83 TSHR (0.54) TSHRTDP1ALDH1A1LMNAMEN1
SCHEMBL9735773 0.82 ALDH1A1 (0.69) TSHRTDP1ALDH1A1GPR35HPGD
SCHEMBL29720550 0.81 TDP1 (0.70) TSHRTDP1ALDH1A1LMNAGPR35
SCHEMBL9734521 0.80 ALDH1A1 (0.67) TSHRTDP1ALDH1A1GPR35HPGD
SCHEMBL774702 0.80 TSHR (0.52) TSHRTDP1ALDH1A1LMNAGPR35
SCHEMBL7835612 0.80 ALDH1A1 (0.61) TSHRTDP1ALDH1A1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106467467-A A kind of method that fixed bed continuous catalytic hydrogenation prepares diaminonaphthalene 南通龙翔化工有限公司 2017-03-01 CN claimed
CN-106467467-A A kind of method that fixed bed continuous catalytic hydrogenation prepares diaminonaphthalene 南通龙翔化工有限公司 2017-03-01 CN disclosed
EP-0686141-B1 NEW PROCESS FOR THE NITRATION OF AROMATIC COMPOUNDS IN MILD, NON-CORROSIVE CONDITIONS INST NACIONAL DE ENGENHARIA E (PT) 1998-12-09 EP disclosed
EP-0686141-A1 NEW PROCESS FOR THE NITRATION OF AROMATIC COMPOUNDS IN MILD, NON-CORROSIVE CONDITIONS INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL (PT) 1995-12-13 EP disclosed
WO-1994019310-A1 NEW PROCESS FOR THE NITRATION OF AROMATIC COMPOUNDS IN MILD, NON-CORROSIVE CONDITIONS INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL (PT) 1994-09-01 WO disclosed
US-4053526-A PROCESS FOR ISOLATING DINITRONAPHTHALENES BAYER AKTIENGESELLSCHAFT (DT) 1977-10-11 US disclosed
US-4026944-A TREATING DINITRONAPHTHALENE WITH HYDROGEN, HYDROGENATION CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1977-05-31 US disclosed