Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203248 | 0.90 | ALDH1A1 (0.38) | BRS3ALDH1A1 | |
| SCHEMBL8672154 | 0.86 | ACHE (0.47) | BRS3BDKRB1AGTR1AGTR2ACHE | |
| SCHEMBL8668602 | 0.86 | BDKRB1 (0.43) | BRS3BDKRB1AGTR1AGTR2SLC6A3 | |
| SCHEMBL8979907 | 0.84 | AGTR1 (0.46) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL8671895 | 0.83 | AGTR1 (0.46) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL8979778 | 0.83 | AGTR1 (0.45) | BRS3BDKRB1AGTR1AGTR2ACHE | |
| SCHEMBL8979838 | 0.82 | AGTR1 (0.44) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL8979794 | 0.80 | AGTR1 (0.46) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL8673071 | 0.80 | BRS3 (0.42) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL8979890 | 0.80 | AGTR1 (0.45) | BRS3AGTR1AGTR2ACHELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804583-A | Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA (IT) | 1998-09-08 | — | — | US | disclosed |
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |