Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.41 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.38 |
| ▸ | ATG7 | O95352 | 1/20 | 0.38 |
| ▸ | UBA7 | P41226 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866864 | 1.00 | AURKA (0.52) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL10149399 | 0.77 | NAE1 (0.47) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL10149398 | 0.76 | AURKA (0.44) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL12392401 | 0.74 | EGFR (0.51) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL866619 | 0.74 | AURKA (0.41) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL10185763 | 0.73 | NAE1 (0.53) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL866432 | 0.73 | NAE1 (0.49) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL3345058 | 0.73 | LMNA (0.53) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL22524329 | 0.73 | AURKA (0.56) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL22524331 | 0.73 | AURKA (0.56) | AURKARPS6KB1EGFRAURKBNAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | disclosed |
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | disclosed |
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | NEDD8, NAE1, UBA3 | AURKA 3108/4885RPS6KB1 2781/4885EGFR 3897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.