Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015110 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL7787847 | 0.79 | PDE4A (0.70) | ALDH1A1KMT2APDE5AMEN1HPGD | |
| SCHEMBL6939960 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL8013228 | 0.77 | PDE5A (0.52) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL4924574 | 0.77 | PDE5A (0.72) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL7505789 | 0.75 | PDE5A (0.57) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL27364625 | 0.71 | MPO (0.53) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL27382271 | 0.71 | PDE5A (0.49) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL7797390 | 0.70 | PDE5A (0.48) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 | |
| SCHEMBL7797387 | 0.70 | PDE5A (0.62) | ALDH1A1KMT2APDE5ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5576322-A | Anti-ischemic 2,4-diaminoquinazolines | EISAI CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |