Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7797866 | 0.79 | PDE4A (0.70) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL6943659 | 0.77 | PDE5A (0.48) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4924574 | 0.77 | PDE5A (0.72) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8668740 | 0.77 | ALDH1A1 (0.48) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL7505789 | 0.75 | PDE5A (0.57) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL27364625 | 0.71 | MPO (0.53) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL27382271 | 0.71 | PDE5A (0.49) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL11047374 | 0.70 | CHEK1 (0.41) | ALDH1A1SMN1; SMN2HTTPOLBKDM4E | |
| SCHEMBL7797433 | 0.70 | PDE5A (0.48) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL7797387 | 0.70 | PDE5A (0.62) | PDE5AKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046206-A | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5576322-A | Anti-ischemic 2,4-diaminoquinazolines | EISAI CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |